conducir vs manejar
Both mean 'to drive', split by region. Conducir in Spain, manejar across Latin America — and manejar means 'handle' in Spain.
conducir
To drive a vehicle. Standard in Spain and in formal contexts everywhere.
Conduce con cuidado.
Drive carefully.
The command you'd hear in Spain.
¿Sabes conducir?
Can you drive?
Saber conducir for the skill. 'Carnet de conducir' = driving licence in Spain.
Conducía un camión.
He drove a lorry.
Imperfect for background. Also a professional word: 'conductor' = driver.
manejar
To drive in Latin America. In Spain it means to handle, operate or manage.
Manejo desde los dieciocho.
I've driven since I was eighteen.
Normal in Mexico, Argentina, Colombia. 'Licencia de manejar' in Mexico.
Maneja muy bien el inglés.
She handles English very well.
Manejar = to handle or command a skill. Used in both regions this way.
No sé manejar este programa.
I don't know how to use this software.
Operating tools or software. In Spain this is the only meaning you'll hear.
Tricky bit
In Spain, 'manejar un coche' is understood but sounds off. In Latin America, 'conducir' is understood and slightly formal. Pick one for your target region.